ClinicalIntelPulse · Clinical Approval Outlook

import { wrapFetchWithPayment } from "@x402/fetch";
import { privateKeyToAccount } from "viem/accounts";

const account = privateKeyToAccount(process.env.PRIVATE_KEY);
const fetchWithPay = wrapFetchWithPayment(fetch, account);

const res = await fetchWithPay("https://clinicalintelpulse.theaslangroupllc.com/api/clinical/approval-outlook", {
  method: "GET",
});
const data = await res.json();

curl -X GET \
  "https://clinicalintelpulse.theaslangroupllc.com/api/clinical/approval-outlook?agency=FDA+%7C+EMA+%7C+both+%28default%3A+both%29&condition=Disease+area+%E2%80%94+e.g.+%22Alzheimer+Disease%22+%7C+%22Multiple+Myeloma%22+%7C+%22NASH%22+%7C+%22Heart+Failure%22+%7C+%22Obesity%22&horizon=12m+%7C+18m+%7C+24m+%28default%3A+18m%29&lang=en+%7C+es+%7C+fr+%7C+de+%7C+ja+%7C+zh+%7C+ko+%7C+pt+%7C+ar+%7C+hi+%28default%3A+en%29" \
  -H "X-PAYMENT: <signed x402 payment>"

{
  "approval_candidates": [
    {
      "approval_probability": 85,
      "drug": "Lecanemab (Leqembi)",
      "ema_status": "CHMP assessment ongoing 2025",
      "fda_status": "Full approval received 2023; expanded label applications pending",
      "key_risk": "ARIA (amyloid-related imaging abnormalities) safety profile limiting real-world use",
      "mechanism": "Anti-amyloid monoclonal antibody (protofibrils)",
      "nctId": "NCT03887455",
      "sponsor": "Eisai / Biogen",
      "trial_result": "Positive — 27% slowing of clinical decline vs placebo (p<0.001)"
    }
  ],
  "approval_rate_context": {
    "disease_area_historical_phase3_success_pct": 55,
    "rare_disease_premium": "Breakthrough therapy designation adds ~15% probability uplift",
    "us_approval_rate_phase3_pct": 58
  },
  "market_context": "Alzheimer's is the highest-value CNS approval category. Any successful amyloid or tau therapy represents $5-15B peak sales potential.",
  "pdufa_calendar": [
    {
      "drug": "Donanemab",
      "indication": "Early symptomatic AD",
      "pdufa_date": "2025-Q2",
      "priority_review": true,
      "sponsor": "Eli Lilly"
    }
  ],
  "query_summary": {
    "agencies": [
      "FDA",
      "EMA"
    ],
    "condition": "Alzheimer Disease",
    "horizon": "18m"
  }
}